MDH — Cucumis sativus

Summary

CsMDH (CSA_6G497060) on cucumber chromosome 6 encodes a malate dehydrogenase with NAD-L-malate dehydrogenase activity (EC 1.1.1.37), belonging to the malate dehydrogenase type 1 family. The gene is associated with the glyoxylate cycle, TCA cycle, malate metabolism, regulation of photorespiration and fatty acid beta-oxidation, and localises to microbodies, plastid stroma, chloroplast inner membrane and the Ycf2/FtsHi complex. It has been connected to respiration rate, photosynthetic rate, high temperature stress response, oxidative stress response, disease tolerance, herbicide sensitivity, zinc sensitivity, and multiple developmental processes including meristem growth, cotyledon development, root cap development, and male and female gamete generation. Associations with cadmium tolerance, hypoxia tolerance, seed viability, germination rate, biomass, and thermotolerance have also been noted. Studies of related genes in other species link the family to metabolic flexibility, heat stress response, chloroplast development under heat stress, and zinc deficiency tolerance.