GPX4 — Cucumis sativus

Summary

CsGPX4 (CSA_6G408810) on cucumber chromosome 6 encodes a phospholipid-hydroperoxide glutathione peroxidase with glutathione peroxidase and peroxidase activities, belonging to the thioredoxin-like superfamily and containing GPX_AS and GPX_CS domains. The gene is associated with cellular detoxification, response to oxidative stress, hydrogen peroxide metabolism, apoptotic signaling, and hormone responses, as well as arachidonic acid and unsaturated fatty acid metabolism, proline breakdown, and water response. It has been linked to traits including hydrogen peroxide content, self-incompatibility, germination rate, stomatal opening, plant height, and salt tolerance, and to phenotypes such as photooxidative tolerance, immune response, drought tolerance, lateral root density, and ferroptosis-like cell death. The encoded protein localizes to the endomembrane system, chloroplast stroma, endoplasmic reticulum, cytosol, and plasmalemma, and participates in glutathione redox reactions. Studies of related genes in other species link the family to oxidative stress tolerance, ethylene signaling, and chilling tolerance.