RDR1 — Cucumis sativus

Summary

CsRDR1 (CSA_5G564290) on cucumber chromosome 5 encodes an RNA-dependent RNA polymerase with RdRP activity (EC 2.7.7.48) and RNA binding capacity, belonging to the RDRP core and RRM_RDR1/2-like domain families. This gene is associated with posttranscriptional gene silencing by RNA, siRNA processing, and positive regulation of gene silencing. It is linked to antiviral defense, viral resistance, and responses to viruses, as well as resistance to fungal pathogens including Sclerotinia sclerotiorum and Fusarium brachygibbosum. Additional associations include cuticular wax biosynthesis, phenylpropanoid anabolism, response to salicylate, hypersensitivity, and drought resistance. The encoded protein localizes to the nucleus and the RNA-directed RNA polymerase complex. Studies of related genes in other species link the family to virus resistance, pathogen defense, and insect herbivore resistance.