NSF — Cucumis melo

Summary

MELO3C020977.2 (CmNSF) on melon chromosome 12 encodes a CDC48-family AAA+ ATPase with multiple molecular functions including ATP-dependent peptidase activity, polyubiquitin-modification-dependent protein binding, and SNARE binding. The gene is associated with a wide range of biological processes, including protein complex disassembly, protein dislocation from the ER, membrane fusion, Golgi organization, mitotic spindle breakdown, photosynthesis light reactions, and chloroplast protein import. It has been linked to numerous agronomically relevant traits such as plant male sterility, pollen fertility restoration, seed longevity, leaf shattering, viral disease response, herbicide sensitivity, nitrate uptake, stem elongation, flowering time, root development, and oxidative stress response. Localization evidence connects the product to the p97-Ufd1-Npl4 complex, M-AAA complex, mitochondrial membranes, chloroplast membrane, nuclear envelope, cell plate, and spindle. Studies of related genes in other species link the CDC48 family to cell division, cytokinesis, seed development, antiviral resistance, salt tolerance, and organ size regulation.