SWC4 — Cucumis melo

Summary

MELO3C015904.2 (CmSWC4) on melon chromosome 2 encodes a Swc4/Dmap1 family protein with ATP-dependent H2AZ histone chaperone activity, histone H4K5 acetyltransferase activity, and histone H3K4me3 reader activity. It is associated with euchromatin binding, transcription corepressor activity, and DNA repair-dependent chromatin remodeling. The gene is linked to numerous developmental and agronomic traits, including fruit shape, sugar content, seed viability, flowering time, inflorescence length, leaf morphology, root development, and disease tolerance. It is associated with petal formation, meristem development, pollen sperm cell differentiation, and responses to cadmium and long-day photoperiodism. The protein localizes to multiple chromatin-modifying complexes, including the SAGA, SWI/SNF, INO80, and SWR-C complexes. Studies of related genes in other species link the family to thermotolerance, ABA response, organ formation, and gametophyte development.