TBP2 — Cucumis melo
Summary
MELO3C007640.2, designated CmTBP2 on melon chromosome 9, encodes a protein with a Myb/SANT DNA-binding domain and a histone H1/H5-like region, and it binds TATA-box binding protein, double-stranded telomeric DNA, nucleosomal DNA, and RNA, and acts as a structural constituent of chromatin. The gene is associated with telomere maintenance, chromosome condensation, nucleosome assembly, DNA-templated transcription initiation, the DNA damage response, and cellular response to UV-C. It is also linked to fruit development and ripening. Associations with disease tolerance and root morphology traits have been noted, and phenotypes connected to the gene include severe growth defects, small seedlings, and complete infertility. Studies of related genes in other species link the family to telomere length regulation and telomeric DNA binding.
Annotations
- Chromosome
- 9
- Related genes
- TBP2, ATPOT1, ETL1, TBP3, TRB1
- GO terms
- telomeric ssDNA binding, Promoter-specific Chromatin Binding, Chromosome Condensation, TBP-class Protein Binding, Structural Constituent Of Chromatin, GO:0000786, Fruit Development, DNA-templated Transcription Initiation
- Publications
- 28298478, 26597966, 8643494, 36903861, 17640338, 35560426, 15489532, 14558660
- Traits
- mitochondrial function, mitophagy, H3K4me3 demethylation, other miscellaneous trait, Severe Growth Defects, Small Seedlings, Complete Infertility, Progressive Telomere shortening with Progressive Telomere Shortening, Telomere Shortening Similar to Related Mutants, Telomere Shortening with Failure to Elongate Telomeres