CAD1 — Cucumis melo

Summary

MELO3C007186.2 (CmCAD1) on melon chromosome 9 encodes a MACPF domain-containing protein of the CAD1/NSL1-like family. The gene is associated with defense responses, including callose deposition, immune response, and programmed cell death (HR-PCD), as well as regulation of salicylic acid metabolism and signaling. It is associated with lignin content, drought tolerance, and responses to sorbitol, salinity, and fungi. CmCAD1 is also linked to flower and root development, dedifferentiation, and water transport. The encoded protein localizes to the extracellular region, plasma membrane, and nucleus. Studies of related genes in other species link the family to heavy metal tolerance (cadmium, zinc, arsenic), salicylic acid accumulation, and phyllosphere microbiota composition, as well as pathogen resistance and necrotrophic fungal sensitivity.