GPX4 — Cicer arietinum

Summary

LOC101512815 (GPX4, CaGPX4) encodes a protein with phospholipid-hydroperoxide glutathione peroxidase, glutathione peroxidase, and peroxidase activities, containing a thioredoxin domain and thioredoxin-like superfamily domain. This chickpea gene on chromosome 4 is associated with cellular response to oxidative stress, response to oxidative stress, and embryo development ending in seed dormancy. The encoded protein localizes to the endomembrane system, endoplasmic reticulum, chloroplast stroma, cytosol, plasmalemma, and cytoplasm. CaGPX4 is associated with salt tolerance, lateral root density, photooxidative tolerance, immune response, and ferroptosis-like cell death. Studies of related genes in other species connect the family to oxidative stress tolerance, ethylene signaling, and drought tolerance, while sequence similarity links extend these associations to lateral root number and oxidative stress response.