GCN2 — Cicer arietinum

Summary

LOC101497225 (CaGCN2) on chickpea chromosome 6 encodes a eukaryotic translation initiation factor 2alpha kinase with protein serine/threonine kinase activity, ATP binding and tRNA binding, and contains a protein kinase domain, RWD domain and anticodon-binding domain. CaGCN2 is associated with regulation of cytoplasmic translational initiation in response to stress, cellular response to amino acid starvation, peptidyl-serine phosphorylation, intracellular signal transduction, defense response, innate immunity, ABA signaling, cortical microtubule organization, and response to herbicide. The gene is linked to phenotypes including sulfonylurea herbicide tolerance, glyphosate sensitivity and tolerance, salt tolerance, cold tolerance, cadmium stress tolerance, oxidative stress response, light stress response, UV-B response, DNA damage response, immune response, nutrient sensing, translation rate, eIF2α phosphorylation, photosynthesis inhibition, and plant growth. CaGCN2 localises to the cytoplasm, nucleus and cortical microtubule. Studies of related genes in other species link the family to stress tolerance, herbicide tolerance, amino acid deprivation tolerance, abscisic acid homeostasis, stomatal immunity, seed germination, leaf morphology and chlorophyll content.