TH2 — Cicer arietinum

Summary

CaTH2 (TH2, PALE1) on chickpea chromosome 4 encodes a thiaminase-2/PQQC domain-containing protein with thiaminase activity and ThMPase activity, placing it in the thiamine salvage TenA family. The gene is associated with thiamin anabolism and thiamin metabolism, as well as immune response and cytokine production. Its product localises to mitochondria and cytosol. Studies of related genes in other species link the family to thiamin diphosphate biosynthesis and variegated yellow-green true leaves. Associations with leaf colour and root morphology traits have been noted through sequence similarity. The gene is also associated with thiamin biosynthesis and metabolism phenotypes.