HIR1 — Capsicum annuum

Summary

CaHIR1 (T459_17730) on pepper chromosome 6 encodes a protein containing a Band7/SPFH domain, characteristic of the hypersensitive-induced response protein family. The gene product is associated with telomeric repeat binding, histidine kinase binding, and ATP hydrolase activity. CaHIR1 is linked to defence responses, including detection of bacteria, response to oomycetes and fungi, and hypersensitive response programmed cell death (HR-PCD). It is also associated with telomere maintenance, meristem maintenance, root meristem growth, and sporulation. The protein localises to the plasmalemma, tonoplast, mitochondria, plastid, and plasmodesmata. Associations with bacterial disease response, disease tolerance, osmotic response sensitivity, seed viability, and flowering time have been reported. Studies of related genes in other species link the HIR1 family to innate immunity, Pseudomonas syringae resistance, and telomere length regulation.