HMA2 — Camelina sativa
Summary
CsHMA3 (CSA12G017090, also known as HMA2) on Camelina sativa chromosome 12 encodes a P-type ATPase of the IB subfamily, a cation-transporting ATPase with activity toward divalent copper, monovalent copper, zinc, cadmium, and calcium, and it binds copper, ATP, ADP, calmodulin, and metal ions. The gene is associated with detoxification of cadmium and copper ions, copper ion homeostasis, membrane transport, detection of bacteria, defence response to bacteria, and the hypersensitive response–programmed cell death pathway. Its product localises to the vacuolar membrane, Golgi membrane, and plasmalemma. CsHMA3 is associated with leaf width and shape, bacterial disease response, disease tolerance, lead tolerance, cadmium detoxification, zinc homeostasis, shoot cadmium concentration, leaf cadmium accumulation, and multiple aspects of bacterial defence and effector-triggered immunity. Related genes in other species connect the family to cadmium, zinc, and cobalt tolerance, cadmium accumulation and transport, and resistance to Pseudomonas syringae.
Annotations
- Chromosome
- 12
- Related genes
- HMA3, HMA2, RPS2
- GO terms
- Response To Toxic Substance, P-type ATPase activity, Detoxification Of Copper Ion, ADP Binding, plasmalemma, P-type Monovalent Copper Transporter Activity, metal binding, copper binding
- Publications
- 30300945, 24377444, 16608451, 17447913, 22880057, 31362467, 17181774, 31550400
- Traits
- disease resistance, cadmium transport, cadmium tolerance, hypersensitive cell death response, other miscellaneous trait, Susceptible to Pseudomonas with avrRpt2, Lacks Hypersensitive Response, Impaired RPM1-Mediated Resistance to Bacterial Effectors, Susceptible to Pseudomonas with avrRpm1, avrB, or avrRpt2