HER2 — Brassica oleracea var. botrytis

Summary

BoHER2 (HER2) on cauliflower chromosome CBFFJS010000039.1 encodes a protein with S-(hydroxymethyl)glutathione dehydrogenase (NAD+, NADP+, and NAD(P)+) activity, aldo-keto reductase (NAD) activity, and binding sites for cobalt and zinc. It contains ADH-like and GroES-like domains. The gene is associated with response to alcohol, methanal catabolism, isoprenoid anabolism, and alkaloid metabolism, and its product localises to the plastid, mitochondria, and cytosol. BoHER2 is associated with responsiveness to E-2-hexenal. Studies of related genes in other species connect the family to reduced root growth inhibition by E-2-hexenal and to alcohol dehydrogenase (EC 1.1.1.1) and S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284) activities.