HMA4 — Brassica oleracea

Summary

BoHMA4 (BOLC102_C07P003870.1) on cabbage chromosome 7 encodes a P-type ATPase of the IB subfamily, annotated with P-type divalent copper transporter activity, cadmium exporting ATPase activity, and zinc ion transmembrane transporter activity. The gene is associated with metal ion transport, copper ion homeostasis, detoxification of copper ion, and response to cadmium, zinc, and cobalt ion. It is linked to cadmium tolerance, cadmium translocation, zinc resistance, leaf zinc concentration, and zinc-cadmium resistance. Additional associations include photosynthetic rate, chlorophyll content, nitrate uptake, seedling growth and development trait, and fungal resistance. The encoded protein localises to the vacuolar membrane, Golgi membrane, plasmalemma, and plasmodesmata. Studies of related genes in other species link the family to zinc translocation, cadmium accumulation, metal homeostasis, and seed zinc content.