HMA4 — Brassica napus

Summary

BnHMA4 (DARMORV10_C03P59470.1) on chromosome C03 of oilseed rape encodes a P-type ATPase of the IB subfamily, with annotated divalent copper, monovalent copper, zinc, cadmium, calcium, potassium, sodium and proton transporter activities, as well as copper binding and protein phosphorylated amino acid binding. The gene is associated with metal ion transport, detoxification of copper ion, copper ion homeostasis, cellular zinc ion homeostasis, response to cobalt ion, response to toxic substance, response to metal, response to zinc, response to cadmium, proton export across plasma membrane, cell pH regulation, pollen germination, and brassinosteroid-mediated signalling. Its product localises to the vacuolar membrane, Golgi membrane, plant-type vacuole, plasmodesma, Golgi complex, membrane, mitochondria, cytosol, plasmalemma, and cytoplasm. BnHMA4 is associated with cadmium tolerance, cadmium translocation, fungal resistance, zinc concentration gradient, zinc-cadmium resistance, leaf zinc concentration, zinc resistance, cadmium resistance, cadmium transport, cadmium sensitivity, zinc ion homeostasis, photosynthetic rate, germination rate, nitrate uptake, stomatal resistance, organ identity, leaf composition trait, and seedling growth and development trait. Studies of related genes in other species link the family to zinc translocation, cadmium accumulation, metal homeostasis, seed zinc content, and heavy metal tolerance.