HMA2 — Brassica napus

Summary

BnHMA2 (DARMORV10_A03P59460.1) on chromosome A03 of oilseed rape encodes a P-type ATPase of the IB subfamily, a heavy-metal-transporting ATPase with copper, zinc, cadmium and calcium transporter activities, ATP binding and calmodulin binding. The gene is associated with detoxification of copper ions, copper and zinc ion homeostasis, proton export across the plasma membrane, cell pH regulation, response to toxic substances, pollen germination and membrane transport. It localises to the vacuolar, Golgi and plasma membranes. Associations with photosynthetic rate, germination rate, stomatal resistance, cadmium tolerance and translocation, zinc partitioning and transport, metal homeostasis, fungal resistance, cadmium accumulation and sensitivity have been reported. Studies of related genes in other species link the family to zinc homeostasis, cadmium transport, xylem loading and long-distance translocation, as well as to leaf chlorosis, chlorophyll content and root length.