HMA2 — Brassica napus

Summary

BnHMA2 (DARMORV10_A01P08030.1) on chromosome A01 of oilseed rape encodes a P-type ATPase of the IB subfamily, a heavy metal-transporting ATPase with domains including HMA and P-type ATPase transmembrane and cytoplasmic regions. The enzyme exhibits P-type divalent copper, monovalent copper, zinc, calcium, and cadmium exporting ATPase activities, as well as copper binding, calmodulin binding, and ATP hydrolase activity. It is associated with detoxification of copper ions, copper and zinc ion homeostasis, response to toxic substances, pollen germination, membrane transport, and response to cold and thirst. The protein localizes to the vacuolar membrane, Golgi membrane, and plasmalemma. BnHMA2 is associated with photosynthetic rate, germination rate, stomatal resistance, cadmium tolerance, translocation, and accumulation, zinc partitioning and transport, metal homeostasis, and fungal resistance. Related genes in other species are linked to zinc homeostasis, cadmium transport, xylem loading, and long-distance translocation.