HPR3 — Brassica juncea

Summary

BJUA06G34080S (BjHPR3, also known as HPPR3) encodes a hydroxypyruvate reductase on chromosome A06 of Indian mustard (Brassica juncea). The product possesses NAD(P)-binding and D-isomer 2-hydroxyacid dehydrogenase catalytic domains and exhibits multiple oxidoreductase activities, including hydroxypyruvate reductase [NAD(P)H], formate dehydrogenase (NAD+), glyoxylate reductase (NADH and NADPH), and D-lactate dehydrogenase (NAD+) activities. BjHPR3 is associated with the oxidative photosynthetic carbon pathway (photorespiration), photorespiratory flux, photochemical efficiency, and plant growth. It is also associated with formate breakdown, fatty acid oxidation, lipogenesis, and heat generation, as well as with myelination, angiogenesis, and fat cell differentiation. The protein localises to mitochondria and cytosol. Related genes in other species are linked to 4-hydroxyphenyllactic acid accumulation and impaired tyrosine conversion.