ICDH — Brachypodium distachyon

Summary

BdICDH (BRADI_5G15210V3) on chromosome 5 of Brachypodium distachyon encodes a protein with isocitrate dehydrogenase NADP, isocitrate/isopropylmalate dehydrogenase, and isopropylmalate dehydrogenase-like domains, and is annotated with EC 1.1.1.42. The protein is associated with NADP isocitric dehydrogenase activity, NAD isocitric dehydrogenase activity, NAD binding, ATP binding, and protein homodimerization activity. It is linked to the TCA cycle, glyoxylate cycle, isocitrate metabolism, NADP metabolism, NAD metabolism, brassinosteroid-mediated signalling, defence response to bacteria, chemotaxis, and response to zinc. The protein localises to chloroplast thylakoid and stroma, mitochondria, plastid, cytosol, plasmalemma, apoplast, and plasmodesmata. BdICDH is associated with photosynthetic rate, root morphology, histone methylation, redox homeostasis, and leaf hydraulic conductivity. Studies of related genes in other species connect the family to drought tolerance, salinity tolerance, relative growth rate, chlorophyll content, net photosynthetic rate, transpiration, stomatal resistance, proline content, and disease tolerance.