HSP70 — Brachypodium distachyon

Summary

BRADI_2G54570V3 (HSP70) on chromosome 2 of Brachypodium distachyon encodes an ATP-dependent protein folding chaperone belonging to the Hsp70 family, with ATP hydrolase activity and heat shock protein binding capability. The gene is associated with protein folding in the endoplasmic reticulum, the ERAD pathway, the unfolded protein response, and protein refolding. It is linked to responses to heat, cold, and stress, as well as heat and cold acclimation, auxin transport and signaling, virus-induced post-transcriptional gene silencing, membrane transport, and cellular homeostasis. The encoded protein localizes to the ER lumen and chaperone complex, cytoplasm, nucleus, chloroplast membrane, tonoplast, and membrane. Studies of related genes in other species link the family to spikelet number and heat tolerance.