ICDH — Brachypodium distachyon

Summary

BRADI_2G08700V3 (ICDH, BdICDH) on chromosome 2 of Brachypodium distachyon encodes an isocitrate dehydrogenase with NADP⁺ and NAD⁺ isocitric dehydrogenase activities (EC 1.1.1.42), containing isocitrate dehydrogenase NADP and isopropylmalate dehydrogenase domains. The gene is associated with the TCA cycle, glyoxylate cycle, NADP and NAD metabolism, isocitrate metabolism, brassinosteroid-mediated signalling, defence response to bacteria, response to zinc, and chemotaxis. It is linked to photosynthetic rate, root morphology, histone methylation, redox homeostasis, and leaf hydraulic conductivity. The encoded protein localises to chloroplast thylakoid and stroma, mitochondria, plastid, cytosol, plasmalemma, apoplast, and plasmodesmata. Studies of related genes in other species connect the family to drought and salinity tolerance, net photosynthetic rate, chlorophyll content, proline content, and pathogen resistance.