HSD2 — Beta vulgaris subsp. vulgaris

Summary

BvHSD2 (HSD2, SOP2) on sugar beet chromosome 4 encodes a short-chain dehydrogenase/reductase (SDR) family protein with a KR domain and NAD(P)-binding domain. The enzyme exhibits multiple annotated activities including estradiol 17-beta-dehydrogenase, 11-beta-hydroxysteroid dehydrogenase, tropinone reductase, and 3-oxoacyl-ACP reductase activity, all NAD-dependent redox functions. The gene is associated with steroid metabolism, tropane alkaloid biosynthesis, and fatty acid biosynthesis. It is linked to response to aldosterone and localises to the endoplasmic reticulum, plasma membrane, cytosol, and extracellular region. Studies of related genes in other species connect the family to diverse metabolic pathways, though these associations are not yet established in sugar beet.