PCNA — Beta vulgaris subsp. vulgaris

Summary

BvPCNA (BVRB_2G024430) on sugar beet chromosome 2 encodes a proliferating cell nuclear antigen, a DNA sliding clamp that is a processivity clamp and also possesses histone H3K27 methylase, SUMO transferase, and damaged DNA binding activities. The gene is associated with DNA replication, repair, and chromatin remodeling processes including bypass DNA synthesis, mismatch repair, interstrand crosslink repair, homologous recombination, and double-strand break repair via synthesis-dependent strand annealing. It is linked to UV light sensitivity, radiation response, oxidative stress response, abscisic acid sensitivity, stomatal opening, flowering time, root morphology, and pollen fertility restoration traits. The protein localizes to the PCNA complex, nucleolus, chloroplast stroma, plasmodesma, and apoplast. Studies of related genes in other species connect the PCNA family to DNA repair, gamma radiation sensitivity, cadmium stress response, female germline development, and immune response.