PPAR — Beta vulgaris subsp. vulgaris

Summary

BVRB_011550 (symbol PPAR) on sugar beet chromosome 0326.scaffold00811 encodes a D-isomer specific 2-hydroxyacid dehydrogenase catalytic domain-containing protein with glyoxylate reductase (NADH), hydroxypyruvate reductase (NADPH), and D-lactate dehydrogenase (NAD+) activities. The gene is associated with diverse biological processes including fatty acid oxidation, gluconeogenesis, lipogenesis, steroidogenesis, mitochondrial biogenesis, cellular respiration, glucose homeostasis, and wound healing. It is also linked to sebocyte differentiation, keratinocyte proliferation, skin development, and response to retinoic acid. The encoded protein localises to the cytosol. Additionally, PPAR is associated with nitrate content. Studies of related genes in other species connect the family to hydroxyphenylpyruvate reductase activities (EC 1.1.1.110, 1.1.1.237).