HSP70 — Asparagus officinalis

Summary

A4U43_C02F1500 (HSP70) on asparagus chromosome 2 encodes a heat shock cognate 70 kDa protein, a member of the Hsp70 family with ATPase and chaperone activity. The gene product binds ATP, hydrolyses ATP, binds heat shock proteins, and acts as a protein folding chaperone. It is associated with the unfolded protein response in the endoplasmic reticulum, the ERAD pathway, protein refolding, and responses to heat, stress, and viruses. Additional associations include progesterone anabolism, steroidogenesis, lipid metabolism, homeostasis, and memory. The protein localises to the cytoplasm, nucleus, membrane, tonoplast, chloroplast membrane, ER lumen, ER chaperone complex, and axonemal central pair projection. Studies of related genes in other species link the family to endoplasmic reticulum stress responses and protein quality control.